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In the authors anecdotal experience, when further uptitration is not tolerated, but treatment effects are noted, maintaining the patient at the lower tolerated dose may be preferable to discontinuation

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B12 shots can quickly replenish these lost nutrients

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Improved glycemic stability supports adherence to nutrition plans and helps mitigate metabolic resistance, particularly in individuals with insulin sensitivity challenges

Applying only statistically significant differences from PIONEER 4 led to similar incremental benefits in quality-adjusted life expectancy (0.18 QALYs) to the base case analysis